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MLA Full: "Eukaryopolis - The City of Animal Cells: Crash Course Biology #4." YouTube, uploaded by CrashCourse, 20 February 2012,
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Hank tells us about the city of Eukaryopolis - the animal cell that is responsible for all the cool things that happen in our bodies.

Table of Contents time codes
1) Robert Hooke 1:59
2) Cilia/Flagella 2:52
3) Cell Membrane 3:32
4) Cytoplasm/Cytoskeleton/Centrosomes 3:58
5) Endoplasmic Reticulum 4:41
6) Ribosomes 5:45
7) Golgi Apparatus 6:00
8) Lysosomes 6:47
9) Nucleus 7:06
10) Mitochondria 9:14

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CC Kids:

 Introduction (00:00)

This is an animal. And this is also an animal. An animal. Animal. Animal carcass. Animal. Animal. Animal carcass again. Animal.

The thing that all of these other things have in common is that they're made out of the same basic building block - the animal cell.

[Intro Music]

Animals are made up of your run-of-the-mill eukaryotic cells and these are called eukaryotic because they have a true "kernel" in the Greek - a good nucleus. And that contains the DNA and calls the shots for the rest of the cell. Also containing a bunch of organelles, a bunch of different kinds of organelles and they all have very specific functions and all this is surrounded by the cell membrane. 

Of course plants are eukaryotic cells too but they are set up a bit differently and of course they have organelles that allow them to make their own food wich is super nice ,we don't have those. And also their cell membrane is actually a cell wall, it's made of cellulose. It's rigid, which is why plants can't dance.  

If you wanna know about plants cells, we did a whole video on it and you can click on it here if it's online yet, it might not be. All lot of the stuff in this video is going to apply to all eukaryotic cells which includes: plants, fungi and protist. 

Now rigid cell walls, that's cool and all but one of the reasons that animals have been so successful is that their flexible membrane, in addition to allowing them the ability to dance, gives animals the flexibility to create a bunch of different cell types and organ types and tissue types that could never be possible in a plant.

The cell walls that protect plants and give them structure prevent them from evolving complicated nerves structures and muscles cells that allow animals to be such a powerful force for, you know, eating plants.

Animals can move around, find shelter and food, find things to mate with, all that good stuff. In fact the ability to move one's self around using specialized muscle tissue has been 100 per cent trademarked by Kingdom-Animalia.

[voice off screen]: Ehh, what about protozoans?

Excellent point! What about protozoans? They don't have specials muscle tissue they move around with cilia and flagella and that kind of thing.

 Robert Hooke (01:59)

So way back in 1665, British scientist Robert Hooke discovered cells with his kind of crude, beta-version microscope. He called them cells because they looked like, ah, bare Spartan monk bedrooms with not much going on inside.

Hooke was a smart guy and everything, but he could not have been more wrong about what was going on inside a cell. There is a whole lot going on inside a eukaryotic cell, it is more like a city then a monk's cell, in fact, let's go with that. A cell is like a city. It has defined geographical limits, a ruling government, power plants, roads, waste treatment plants, a police force, industry; all the things a booming metropolis needs to run smoothly. But, this city does not have one of those hippie governments where everyone votes on stuff and talks things out at town hall meetings and crap like that, Nope! Think Fascist Italy, circa 1938. Think Kim Jong Il's-- I mean Kim Jong Un's North Korea and you might be getting a closer idea how Eukaryotic cells do their business.

 Cilia/Flagella (02:50)

Let's start out with city limits. So as you approach the city of Eukaryopolis there is a chance that you will notice something that a traditional city never has, which is either cilia or flagella. Some eukaryotic cells have either one or the other of these structures, cilia being a bunch of tiny little arms that wiggle around, flagella being one, long whip-like tail. Some cells have neither; sperm cells, for instance, have flagella, and our lungs and throat cells have cilia that push mucus up and out of our lungs. Cilia and flagella are made out of long protein fibers called microtubules and they both have the same basic structure: nine pairs of microtubules forming a ring around two central microtubules. This is often called the nine plus two structure. Anyway, that's just so you know that when you're approaching this city, watch out for the cilia and flagella!

 Cell Membrane (03:31)

If you make it past the cilia, you will encounter what is called a cell membrane, which is a kind of squishy, not-rigid plant cell wall which totally encloses the city and all of its contents. It's also in charge of monitoring what comes in and out of the cell, kind of like the fascist border police. The cell membrane has selective permeability, meaning that it can choose what molecules come in and out of the cell, for the most part. I did an entire video on this, which you can check out right here.

 Cytoplasm/Cytoskeleton/Centrosomes (03:58)

Now the landscape of Eukaryopolis, important to note, is kind of wet and squishy, bit of a swampland. Each eukaryotic cell is filled with a solution of water and nutrients called cytoplasm, and inside of this cytoplasm is a scaffolding called the cytoskeleton. It's basically just a bunch of protein strands that reinforce the cell. Centrosomes are a special part of this reinforcement; they assemble long microtubules out of proteins that act like steel girders that hold all the city's buildings together. The cytoplasm provides the infrastructure necessary for all the organelles to all their awesome, amazing business, with the notable exception of the nucleus, which has its own kind of cytoplasm called the nucleoplasm, which is more luxurious, premium environment befitting the cell's beloved leader.

 Endoplasmic Reticulum (04:40)

But we'll get to that in a minute. First, let's talk about the cell's highway system. The endoplasmic reticulum, or just ER, are organelles that create a network of membranes that carry stuff around the cell. These membranes are phospholipid bilayers, same as in the cell membrane. There are two types of ER, there's the rough and the smooth, fairly similar but slightly different shapes, slightly different functions.

The rough ER looks bumpy because it has ribosomes attached to it, and the smooth ER doesn't, it's it's a smooth network of tubes. Smooth ER acts as a kind of factory-warehouse in the cell city. It contains enzymes that help with the creation of important lipids, which you'll recall from our talk about biological molecules --i.e. phospholipids and steroids that turn out to be sex hormones. 

Other enzymes in the smooth ER specialize in detoxifying substances, like noxious stuff derived from drugs and alcohol, which they do by adding a carboxyl group to them, making them soluble in water.  Finally, the smooth ER also stores ions in solutions that the cell may need later on, especially sodium ions, which are used for energy in muscle cells. So the smooth ER helps make lipids, while the rough ER helps in the synthesis and packaging of proteins.

 Ribosomes (05:45)

And those proteins are created by another type of organelle- the ribosome. Ribosomes can float freely throughout the cytoplasm or be attached to the nuclear envelope, which is where they're spat out from, and their job is to assemble amino acids into polypeptides.

 Golgi Apparatus (05:55)

As the ribosome builds an amino acid chain, the chain is pushed into the ER. When the protein chain is complete, the ER pinches it off and sends it to the Golgi Apparatus. In the city that is a cell, the Golgi is the post office, processing proteins and packaging them up before sending them wherever they need to go. Calling it an apparatus makes it sound like a bit of complicated machinery which it kind of is, because it's made up of like these stacks of membranous layers that are sometimes called Golgi bodies.
The Golgi bodies can cut up large proteins into smaller hormones and can combine proteins with carbohydrates to make various molecules, like, for instance, snot. The bodies package these little goodies into sacs called vesicles, which have phospholipid walls just like the main cell membrane, then ships them out, either to other parts of the cell or outside the cell wall. We learn more about how vesicles do this in the next episode of Crash Course.

 Lysosomes (6:47)

The Golgi bodies also put the finishing touches on the lysosomes. Lysosomes are basically the waste treatment plants and recycling centers of the city. These organelles are basically sacks full of enzymes that break down cellular waste and debris from outside of the cell  and turn it into simple compounds, which are transferred into the cytoplasm as new cell-building materials. 

 Nucleus (07:06)

Now, finally, let us talk about the nucleus, the Beloved Leader. The nucleus is a highly specialized organelle that lives on its own double-membraned, high-security compound with its buddy the nucleolus. And within the cell, the nucleus is in charge in a major way. Because it stores the cell's DNA, it has all the information the cell needs to do its job. 

So the nucleus makes all the laws for the city and orders the other organelles around, telling them how and when to grow, what to metabolize, what proteins to synthesize, how and when to divide. The nucleus does all this by using the information blueprinted in its DNA to build proteins that will facilitate a specific job getting done.

For instance, on January 1st ,2012 let's say a liver cell needs to help break down an entire bottle of champagne. The nucleus in that liver cell would start  telling the cell to make alcohol dehydrogenase, which is the enzyme that makes alcohol not-alcohol anymore. This protein synthesis business is complicated, so lucky for you, we will have or may already have an entire video about how it happens. 

The nucleus holds its precious DNA, along with some proteins, in a web-like substance called the chromatin. When it comes time for the cell to split, the chromatin gathers into rod-shaped chromosomes, each of which holds DNA molecules. Different species of animals have different numbers of chromosomes. We humans have 46. Fruit flies have 8. Hedgehogs, which are adorable, but you know, are less complex than humans and have 90. 

Now the nucleolus, which lives inside the nucleus, is the only organelle that's not enveloped by its own membrane-- it's just a gooey splotch of stuff within the nucleus.  It's main job is creating ribosomal RNA or rRNA, which it then combines with some proteins to form the basic units of ribosomes. Once these units are done, the nucleolus spits them out of the nuclear envelope, where they are fully assembled into ribosomes. 

The nucleus then sends orders in the form of messenger RNA or mRNA, to those ribosomes, which are the henchmen that carry out the orders in the rest of the cell. How exactly the ribosome do this is immensely complex and awesome, so awesome, in fact, that we're going to give it the full Crash Course treatment in an entire episode.

 Mitochondria (09:13)

And now, for what is, totally objectively speaking of course, the coolest part of an animal cell: its power plants! The mitochondria are these smooth, oblong organelles where the amazing and super-important process of respiration takes place. This is where energy is derived from carbohydrates, fats, and other fuels and is converted into adenosine triphosphate or ATP, which is like the main currency that drives life in Eukaryopolis. You can learn more about ATP and respiration in an episode that we did on that. 

Now of course, some cells, like muscle cells or neuron cells need a lot more power than the average cell in the body, so those cells have a lot more mitochondria per cell. But maybe the coolest thing about mitochondria is that long ago animal cells didn't have them, but they existed as their own sort of bacterial cell. And, eh, one day, one of these things ended up inside of an animal cell, probably because the animal cell was trying to eat it, but instead of eating it, it realized that this thing was really super smart and good at turning food into energy and it just kept it. It stayed around. And to this day they sort of act like their own, separate organisms, like they do their own thing within the cell, they replicate themselves, and they even contain a small amount of DNA.

Now what's maybe even more awesome --if that's possible-- is that mitochondria are in the egg cell when an egg gets fertilized, and those mitochondria have DNA. But because mitochondria replicate themselves in a separate fashion, it doesn't get mixed with the DNA of the father, it's just the mother's mitochondrial DNA. That means that you and my mitochondrial DNA is exactly the same as the mitochondrial DNA of our mothers. And because of this special DNA is isolated in this way, scientists can actually trace back and back and back and back to a single "Mitochondrial Eve" who lived about 200,000 years ago in Africa. 

 Conclusion (10:58)

All of that complication and mystery and beauty in one of the cells of your body. It's complicated, yes. But worth understanding. 

Review time! Another somewhat complicated episode of Crash Course: Biology. If you want to go back and watch any of the stuff that we talked about to reinforce it in your brain or if you didn't quite get it, just click on the links and it'll take you back in time to when I was talking about them mere minutes ago. 

Thank you for watching. If you have questions for us, please ask below in the comments, or on Twitter, or on Facebook. And we will do our best to make things more clear for you. 

We'll see you next time.