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| Duration: | 30:19 |
| Uploaded: | 2026-08-22 |
| Last sync: | 2026-08-22 19:00 |
Moderna and Merck announced that they have completed a Phase 3 trial for a vaccine that significantly improves outcomes for people with melanoma (the most deadly form of skin cancer.)
This is very exciting...but /how/ exciting is it? And could it mean not just a new cancer therapy but a whole new /class/ of cancer therapies? I think it could very well be both.
SOURCES
THE PRESS RELEASE
https://www.merck.com/news/merck-and-moderna-announce-phase-3-interpath-001-trial-of-intismeran-autogene-plus-keytruda-met-endpoints-of-recurrence-free-survival-rfs-and-distant-metastasis-free-survival-dmfs-in-patient/
Melanoma staging and mutations
https://www.cancer.gov/types/skin/patient/melanoma-treatment-pdq
https://pmc.ncbi.nlm.nih.gov/articles/PMC4580370/
Keytruda and checkpoint inhibitors
https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/checkpoint-inhibitors
https://www.cancer.gov/about-cancer/treatment/drugs/pembrolizumab
immune-mediated colitis
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9333c79b-d487-4538-a9f0-71b91a02b287
MHC I
https://www.ncbi.nlm.nih.gov/books/NBK459467/
How the therapy works
https://www.merck.com/news/merck-and-moderna-announce-phase-3-interpath-001-trial-of-intismeran-autogene-plus-keytruda-met-endpoints-of-recurrence-free-survival-rfs-and-distant-metastasis-free-survival-dmfs-in-patient/
https://doi.org/10.1200/JCO-26-00835
Clinical Trial for just the Covid vaccine plus keytruda
https://clinicaltrials.gov/study/NCT07597070?utm_source=chatgpt.com
The paper that identified the weird effect with covid vaccines and keytruda
https://www.nature.com/articles/s41586-025-09655-y?utm_id=97760_v0_s00_e0_tv4
This is very exciting...but /how/ exciting is it? And could it mean not just a new cancer therapy but a whole new /class/ of cancer therapies? I think it could very well be both.
SOURCES
THE PRESS RELEASE
https://www.merck.com/news/merck-and-moderna-announce-phase-3-interpath-001-trial-of-intismeran-autogene-plus-keytruda-met-endpoints-of-recurrence-free-survival-rfs-and-distant-metastasis-free-survival-dmfs-in-patient/
Melanoma staging and mutations
https://www.cancer.gov/types/skin/patient/melanoma-treatment-pdq
https://pmc.ncbi.nlm.nih.gov/articles/PMC4580370/
Keytruda and checkpoint inhibitors
https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/checkpoint-inhibitors
https://www.cancer.gov/about-cancer/treatment/drugs/pembrolizumab
immune-mediated colitis
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9333c79b-d487-4538-a9f0-71b91a02b287
MHC I
https://www.ncbi.nlm.nih.gov/books/NBK459467/
How the therapy works
https://www.merck.com/news/merck-and-moderna-announce-phase-3-interpath-001-trial-of-intismeran-autogene-plus-keytruda-met-endpoints-of-recurrence-free-survival-rfs-and-distant-metastasis-free-survival-dmfs-in-patient/
https://doi.org/10.1200/JCO-26-00835
Clinical Trial for just the Covid vaccine plus keytruda
https://clinicaltrials.gov/study/NCT07597070?utm_source=chatgpt.com
The paper that identified the weird effect with covid vaccines and keytruda
https://www.nature.com/articles/s41586-025-09655-y?utm_id=97760_v0_s00_e0_tv4
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